Journal of Petrochemical Universities

Journal of Petrochemical Universities ›› 2011, Vol. 24 ›› Issue (6): 46-49.DOI: 10.3696/j.issn.1006-396X.2011.06.012

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Efficient "One-Pot" Synthesis of 2,3-Dihydro-4(1H)-Quinazolinones

  

  1. 1. Center for Science & Technology Experiment, Liaoning Province Silicon Materials Engineering Technology Research Centre, Bohai University, Jinzhou Liaoning 121000,P.R.China;
    2.College of Chemistry, Chemical Engineering and Food Safety, Bohai University, Jinzhou Liaoning 121000,P.R.China
  • Received:2011-11-25 Published:2011-12-25 Online:2011-12-25

一锅法暠合成2,3-二氢-4(1H)- 喹唑啉酮衍生物

宋志国1,王洋1,孙啸虎1,刘连利1,张婷婷2   

  1. 1.渤海大学科技实验中心,辽宁省硅材料工程技术研究中心;2.渤海大学化学化工与食品安全学院,
  • 作者简介:宋志国(1975-),男,辽宁抚顺市,实验师
  • 基金资助:
    辽宁省硅材料工程中心(2009402007)
    辽宁省博士科研启动基金资助项目(2009A033)
    辽宁省教育厅科学研究资助项目(L2011198)

Abstract:

2,3-Dihydro-4(1H)-quinazolinones derivatives were synthesized efficiently by a three components one-pot reaction of isatoic anhydride, aromatic aldehydes, ammonium salts or primary amines in the presence of aluminum chloride in alcohol-water solution. The structures of products were characterized by IR, 1H-NMR, 13C-NMR, MS techniques and elemental analysis. Compared to the reported methods, this protocol have advantages of short reaction time, high yield, simple experimental and work-up procedures, and environmentally benign procedure. 

Key words: 2,3-Dihydro-4(1H)-quinazolinones, Alumiunm chloride, One-pot synthesis, Multicomponent reaction

摘要: 在醇水溶液中,氯化铝可有效催化靛红酸酐、芳香醛和铵盐/伯胺三组分“一锅法”合成单取代和双取代2,3-二氢-4(1H)-喹唑啉酮衍生物。产品结构经IR, 1H-NMR, 13C-NMR, 质谱和元素分析进行表征。与已报道的合成方法相比,该方法具有反应时间短、收率高、实验操作和后处理步骤简单、对环境友好等优点。

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Cite this article

SONG Zhi-guo,WANG Yang,SUN Xiao-hu.

Efficient "One-Pot" Synthesis of 2,3-Dihydro-4(1H)-Quinazolinones
[J]. Journal of Petrochemical Universities, 2011, 24(6): 46-49.

宋志国,王洋,孙啸虎刘连利,张婷婷. 一锅法暠合成2,3-二氢-4(1H)- 喹唑啉酮衍生物[J]. 石油化工高等学校学报, 2011, 24(6): 46-49.