Synthesis of 4⁃Phenyl⁃3⁃Butene⁃2⁃Ketone Compound

doi:10.3969/j.issn.1672-6952.2020.06.003

Journal of Liaoning Petrochemical University ›› 2020, Vol. 40 ›› Issue (6): 10-13.DOI: 10.3969/j.issn.1672-6952.2020.06.003

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Synthesis of 4⁃Phenyl⁃3⁃Butene⁃2⁃Ketone Compound

Li Ya'nan¹， Liu Zhibo²， Yu Fang¹

1.School of Petrochemical Engineering， Liaoning Shihua University， Fushun Liaoning 113001， China； 2.Fushun Petrochemical Beitian Shunda Company， Fushun Liaoning 113006， China

Received:2019-04-12 Revised:2020-04-13 Published:2020-12-25 Online:2020-12-30

4⁃苯基⁃3⁃丁烯⁃2⁃酮的合成

李亚楠¹，刘志波²，于芳¹

1.辽宁石油化工大学石油化工学院，辽宁抚顺 113001； 2.抚顺石化北天顺达公司，辽宁抚顺 113006

通讯作者: 于芳(1980-)，女，博士，副教授，从事过渡金属催化的有机合成研究；E-mail：yufang1112002@163.com。
作者简介:李亚楠(1991-)，女，硕士研究生，从事有机合成研究；E-mail：18340315291@163.com。
基金资助:
国家自然科学基金项目(21402078)。

Abstract

Abstract: A synthetic method for forming α,β⁃unsaturated ketones through aldol condensation was studied. The formation of C-C bonds of 4⁃phehyl⁃3⁃buten⁃2⁃one was achieved under a metal⁃free condition in the presence of NaOH. The reaction conditions were mild and the selectivity was strong.The reaction mechanism was measured and the structure of the target product was analyzed by various characterization methods to confirm the structure of the target product.

Key words: Aldol condensation, α, β?unsaturated ketone, Metal?free

摘要： 研究了一种经羟醛缩合形成α,β⁃不饱和酮的合成方法。该反应在NaOH的催化作用下，使苯甲醛和丙酮在无金属条件下构建C-C，合成4⁃苯基⁃3⁃丁烯⁃2⁃酮，反应条件温和，选择性强。推测了反应机理，并通过各种表征手段对目标产物结构进行分析，确认目标产物结构。

关键词: 羟醛缩合, α,β?不饱和酮, 无金属

Li Ya'nan， Liu Zhibo， Yu Fang. Synthesis of 4⁃Phenyl⁃3⁃Butene⁃2⁃Ketone Compound[J]. Journal of Liaoning Petrochemical University, 2020, 40(6): 10-13.

李亚楠，刘志波，于芳. 4⁃苯基⁃3⁃丁烯⁃2⁃酮的合成[J]. 辽宁石油化工大学学报, 2020, 40(6): 10-13.

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Synthesis of 4⁃Phenyl⁃3⁃Butene⁃2⁃Ketone Compound

4⁃苯基⁃3⁃丁烯⁃2⁃酮的合成

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