石油化工高等学校学报

石油化工高等学校学报 ›› 2010, Vol. 23 ›› Issue (3): 1-5.DOI: 10.3696/j.issn.1006-396X.2010.03.001

• 石油化工 •    下一篇

功能化SBA－15－NH2在药物布洛芬吸附与控制释放的研究

孙丽娜，张晓彤，陈雷，张翻，潘明雪，宋丽娟   

  1. 辽宁石油化工大学辽宁省石油化工重点实验室,辽宁抚顺 113001
  • 收稿日期:2010-06-08 修回日期:2010-06-24 出版日期:2010-09-25 发布日期:2010-09-25
  • 作者简介:孙丽娜(1985 -), 女, 吉林四平市, 在读硕士
  • 基金资助:
    国家自然基金资助项目(20976077)。

Functionalized SBA － 15 Materials as Carriers for Adsorption and Controlled Drug Delivery

  1. Liaoning Key Laboratory of Petrochemical Engineering, Liaoning Shihua University, Fushun Liaoning 113001, P.R.China
  • Received:2010-06-08 Revised:2010-06-24 Published:2010-09-25 Online:2010-09-25

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摘要：

采用合成后改性法将氨基嫁接进介孔SBA-15孔道内，对功能化的SBA-15进行药物吸附与控制释放研究。利用X射线衍射(XRD)、智能重量分析仪(IGA)、透射电镜(TEM)、红外光谱仪(IR)等表征手段对它的物理结构、化学组成进行表征，在此基础上，利用分子模拟软件对其空间骨架结构及与药物分子之间的相互作用进行模拟。对目标药物布洛芬(IBU)负载进改性前后的SBA-15材料内表面进行研究。结果表明，药物吸附和缓释性能与SBA-15材料内表面官能团有着密切的关系。由于药物IBU分子与功能化SBA-15-NH2内表面的氨基基团之间存在离子相互作用，故其药物释放时间比单纯的SBA-15更长。
 

关键词: SBA － 15 , 布洛芬 , 药物缓释 , 吸附

Abstract:

Mesoporous SBA-15 materials were functionalized with amine groups through postsynthesis, and resulting functionalized material was investigated as matrix for controlled drug delivery. The structure, composition and framework of the material were investigated by means of X-ray diffraction (XRD), intelligent weight analyzer (IGA), transmission scanning electron microscopy (TEM), infrared spectrometer (IR), and molecular simulation software. Ibuprofen (IBU) was selected as model drug and loaded onto the unmodified and functionalized SBA-15. It was revealed that the adsorption capacities and release behaviors of this model drug were highly dependent on the surface properties of SBA-15 materials. The release rate of IBU from SBA-15 functionalized by postsynthesis is found to be effectively controlled as compared to that from pure SBA-15 due to the ionic interaction between carboxyl groups in IBU and amine groups on the surface of SBA-15.

Key words: SBA － 15 , Ibuprofen , Drug delivery , Adsorption

引用本文

孙丽娜，张晓彤，陈雷. 功能化SBA－15－NH2在药物布洛芬吸附与控制释放的研究[J]. 石油化工高等学校学报, 2010, 23(3): 1-5.

SUN Li-na, ZHANG Xiao-tong, CHEN Lei,et al. Functionalized SBA － 15 Materials as Carriers for Adsorption and Controlled Drug Delivery[J]. Journal of Petrochemical Universities, 2010, 23(3): 1-5.

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