Abstract: Chiral pyridinone scaffolds widely exist in natural products and biologically active small molecules. Therefore, asymmetric catalytic synthesis with higher efficiency of these chiral compounds is of great importance, which has got significant improvement in this field recently.We reviewed the recent progress of asymmetric synthesis of dihydropyridinones through asymmetric cycloaddition reactions, compared the common points and differences between Aza⁃Diels⁃Alder reactions and [3 + 3] cycloadditions. The detailed catalytic mechanisms and advantages of these reactions were discussed, and the tendency of future development was also prospected.

Key words: Dihydropyridinones, Asymmetric catalysis, Aza?Diels?Alder reaction, [3+3] Cycloaddition

摘要： 手性吡啶酮骨架广泛存在于天然产物和具有生理活性的小分子药物中，实现该类手性结构的高效不对称催化合成具有重要的意义。总结了近年来发展的通过不对称环催化反应合成二氢吡啶酮的研究进展，详细阐述了氮杂⁃D⁃A反应与[3+3]不对称环加成反应的各类催化模式以及它们之间的异同点，分析了各类催化剂的催化原理以及在它们作用下的反应历程，着重介绍了各方法的优势所在，并对该领域的发展进行了展望。

关键词: 二氢吡啶酮, 不对称催化, 氮杂Diels?Alder反应, [3+3]环加成