Release Kinetic Model Studies of Functionalized Mesoporous Materials SBA-15 as Aspirin Carriers

doi:10.3969/j.issn.1006-396X.2012.02.001

Journal of Petrochemical Universities ›› 2012, Vol. 25 ›› Issue (2): 1-4.DOI: 10.3969/j.issn.1006-396X.2012.02.001

Liaoning Key Laboratory of Petrochemical Engineering, Liaoning Shihua University, Fushun Liaoning 113001, P.R. China

Received:2011-12-13 Revised:1900-01-01 Published:2012-04-25 Online:2012-04-25

功能化SBA-15在药物阿司匹林缓释的动力学模型

张晓彤,梁俊虎,任创,葛翠年,段林海,宋丽娟

辽宁石油化工大学辽宁省石油化工重点实验室

作者简介:张晓彤（１９７０－），男，辽宁抚顺市，副教授，在读博士
基金资助:
国家自然科学基金资助项目（２０９７６０７７）；辽宁省
教育厅资助项目（２００８Ｔ１１０，２００７Ｒ２９）。

Abstract

Abstract: Mesoporous materials SBA-15 and SBA-15-NH2 were investigated as the water-insoluble aspirin carrier for controlled drug delivery. The samples structure，drug loading and release profiles were characterized by means of Fourier transform infrared spectroscopy (FT-IR) and UV-spectrophotometer(UV), meantime the release kinetics were analyzed using following mathethematical models Korsmeyer-Peppas equation and Higuchi equation. The results show that the adsorption capacity and release properties of SBA-15 for drug molecules can be improved by functionalizing its surfaces with amine groups, the adsorption of aspirin from 14.2% to 19.5%. The release process of SBA-15-Aspirin follow a Fickian diffusion mechanism, and SBA-15-NH2-Aspirin follow a Non-Fickian diffusion mechanism.

Key words: SBA-15, Aspirin, Drug delivery, Kinetic model

摘要： 采用两种介孔分子筛（ＳＢＡ－１５和ＳＢＡ－１５－ＮＨ２）分别对水溶性药物阿司匹林进行药物吸附与释放的对比研究，利用ＦＴ－ＩＲ，ＵＶ等手段对样品结构、药物装载和释放过程进行表征。同时，运用Ｋｏｒｓｍｅｙｅｒ－Ｐｅｐｐａｓ和Ｈｉｇｕｃｈｉ模型分别对药物缓释体系进行动力学研究。结果表明，氨基改性后ＳＢＡ－１５对阿司匹林的吸附量由１４．２％提高到１９．５％，且释放时间更长。ＳＢＡ－１５－ＡＳＰ缓释系统的释放动力学过程遵循Ｆｉｃｋ扩散机理，而ＳＢＡ－１５－ＮＨ２－ＡＳＰ释放过程遵循非Ｆｉｃｋ扩散机理。

关键词: ＳＢＡ－１５ , 阿司匹林 , 药物缓释 , 动力学模型

ZHANG Xiao-tong, LIANG Jun-hu, REN Chuang, et al. Release Kinetic Model Studies of Functionalized Mesoporous Materials SBA-15 as Aspirin Carriers[J]. Journal of Petrochemical Universities, 2012, 25(2): 1-4.

张晓彤,梁俊虎,任创,葛翠年. 功能化SBA-15在药物阿司匹林缓释的动力学模型[J]. 石油化工高等学校学报, 2012, 25(2): 1-4.

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