Abstract: Azelaic acid was synthesized from oleic acid by ozone and hydrogen peroxide as an oxidant jointly. According to the L9 (34) orthogonal form the four factors (including the concentration of hydrogen peroxide, the flow of ozone, different types of tungsten compounds and phase transfer catalyst) on the yield of azelaic acid were investigated under three different conditions. The results show that the yield of azelaic acid Is up to 70.0% under the following condition: oleic acid 20 g, 30% hydrogen peroxide solution 60 mL, phosphotungstic acid hydrate 0.6 g, CTAB 0.5 g, the concentration of Ozne 4 000 mg/m3. The reaction mechanism of azelaic acid synthesis was also studied, and found that •OH is an important reactant.

摘要： 以过氧化氢和臭氧联合为氧化剂，油酸为原料制备壬二酸的工艺进行了研究。根据正交实验L9 (34 )表格设计，考察了不同的过氧化氢的浓度、通入臭氧的流速以及不同种类钨化合物与季铵盐组成的相转移催化体系等4个因素在3种不同水平条件下对壬二酸收率的影响。结果表明,以20 g油酸为原料，滴加30%H2O2 60 mL，加入0.6 g磷钨酸，0.5 g十六烷基三甲基溴化铵，通入臭氧质量浓度为4 000 mg/m3，壬二酸收率为70.0%。探索了臭氧-过氧化氢联合氧化法制备壬二酸的反应机理，发现•OH 是一个重要的反应物。

关键词: 壬二酸, 正交实验, 臭氧, 过氧化氢, 反应机理