Abstract: 2′,4′,6′-Trimethyl-2-chloro-acetophenone was catalytic synthesized from mesitylene which was obtained from by-product C₉ aromatic hydrocarbons, the refinery and chloroacetyl chloride with Friedel-Crafts acylation reaction by metal loaded catalyst. The influencing factors in the reaction were studied by the contrastive experimental results. The results show that metal loaded catalyst has a better catalytic activity for the acylation reaction of mesitylene and chloroacetyl chloride. The study on optimization of reaction conditions indicates that the yield of acylation reaction at 80 ℃ was over 91.2% after 4 h when the mole ratio of chloroacetyl chloride and mesetylene to loaded metal catalyst was 2∶1∶0.002 5. The compound was identified by refractive index and IR spectrum.

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摘要： 以炼厂副产品C₉ 芳烃中的均三甲苯和氯乙酰氯为原料,用金属负载型催化剂,经Friedel-Crafts酰
基化反应合成了2',4',6'-三甲基-2-氯苯乙酮。通过多组对比实验研究了反应过程的影响因素。实验结果表
明,金属负载型催化剂对实现均三甲苯与氯乙酰氯的酰化反应具有良好的催化性能。通过优化反应条件,确定了反
应的最佳实验条件为:n(均三甲苯)/n(氯乙酰氯)为1∶2,催化剂质量占均三甲苯质量的0.25%,反应时间4h,反应
温度80℃,收率大于91.2%。产品经折光率、红外光谱鉴定为2',4',6'-三甲基-2-氯苯乙酮。

关键词: 2',4',6'-三甲基-2-氯苯乙酮  ,  ,  均三甲苯  ,    ,  酰基化反应 ,   , 催化剂