Abstract: The inclusion compounds of carbofuran with β-cyclodextrin (β-CD) were prepared by kneading method and aqueous-solution method. The properties of the compound were investigated by FT-IR spectra, UV-vis spectra and Fluorescence spectra. The solubility of carbofuran in aqueous solution increased in the presence of β-cyclodextrin due to complex using UV-spectrophotometric measurements. The results show that 1∶1 inclusion complexes are formed between β-CD and carbofuran. The intrinsic fluorescence of carbofuran can be enhanced by β-CD. The binding constants are obtained according to the Stern-Volmer equation. The corresponding thermodynamic parameters ΔH, ΔG and ΔS are calculated. Their values suggested that enthalpy and entropy are the main driving force for the inclusion reaction.

Key words: β-Cyclodextrin, Carbofuran, Phase solubility method, Inclusion, Spectral analysis, Thermodynamics

摘要： 采用固相共研磨法和饱和水溶液法合成β -环糊精和克百威的包合物, 通过红外、紫外和荧光光谱对其结构和性质进行了表征;利用紫外光谱研究了不同浓度下β -环糊精溶液对克百威溶解度的影响, 绘制出相溶解曲线图以确定β -环糊精和克百威之间形成物质的量比为1 ∶1 的包合物。利用克百威的内源荧光特性, 根据包合前后以及在不同温度下荧光强度变化, 结合S te rn -Vo lmer 方程, 获取不同温度下β-环糊精和克百威之间的结合常数Kc ;热动力学方法研究温度对包合反应的影响, 根据热力学参数得出包合反应是自发熵和焓共同驱动过程。

关键词: β-环糊精 , 克百威 , 相溶解度法 , 包合物 , 光谱分析 , 热力学