Abstract: Periconansons C⁃F is a natural product of cytochalasin. Its structure contains a six and six bicyclic skeleton. We think that we can complete the construction of this skeleton structure through one⁃step D⁃A reaction. We synthesized its key D⁃A reaction intermediate.KF is used as base and O2 is used as oxidant to oxidize the required hydroxyl group. After the intramolecular D⁃A reaction, it is possible to complete the total synthesis of four molecules, such as percoannosins C-F.

Key words: Synthesis of intermediate, Pericoannosin, Cytochalasin

摘要： Pericoannosins C⁃F是一种细胞松弛素类天然产物，其结构中包含一个六并六的双环骨架，该骨架单元可以通过一步D⁃A反应予以构建。对其关键D⁃A反应所需的中间体进行了合成。在以氟化钾为碱、氧气为氧化剂的条件下，氧化得到所需的羟基后，经过分子内D⁃A反应全合成Pericoannosins C⁃F等四个分子。

关键词: 中间体合成, Pericoannosin, 细胞松弛素