温度响应性玻璃球基复合载体的制备及表征

doi:10.3969/j.issn.1672-6952.2021.01.005

辽宁石油化工大学学报 ›› 2021, Vol. 41 ›› Issue (1): 23-29.DOI: 10.3969/j.issn.1672-6952.2021.01.005

温度响应性玻璃球基复合载体的制备及表征

安琪¹，李海斌²，张琪¹，杨磊¹，范晓光³，王战勇¹

1.辽宁石油化工大学石油化工学院，辽宁抚顺 113001； 2.锦州市绿源危险废物处置有限公司，辽宁锦州 121229； 3.沈阳农业大学工程学院，辽宁沈阳 110866

收稿日期:2019-08-07 修回日期:2019-09-30 出版日期:2021-02-26 发布日期:2021-03-12
通讯作者: 杨磊（1982-），女，博士，副教授，从事智能材料和生物材料方面的研究；E-mail：leiyang1982@yahoo.com。
作者简介:安琪（1997-），女，本科生，生物工程专业，从事智能材料研究；E-mail：807350595@qq.com。
基金资助:
国家自然科学基金项目（21604034）；辽宁省博士启动基金项目（20170520391）；辽宁省大学生创新创业训练计划项目（201710148000026）。

Preparation and Characterization of Thermoresponsive Glass Sphere Based Composite Carriers

An Qi¹， Li Haibin²， Zhang Qi¹， Yang Lei¹， Fan Xiaoguang³， Wang Zhanyong¹

1.School of Petrochemical Engineering， Liaoning Petrochemical University， Fushun Liaoning 113001， China；
2.Jinzhou Luyuan Hazardous Waste Disposal Co. Ltd.， Jinzhou Liaoning 121229， China；

Received:2019-08-07 Revised:2019-09-30 Published:2021-02-26 Online:2021-03-12

摘要/Abstract

摘要： 报道了一种新型的智能响应性玻璃球基复合载体的制备方法。首先通过自由基聚合法将双键类单体N⁃异丙基丙烯酰胺、甲基丙烯酸羟丙酯和甲基丙烯酸（3⁃三甲氧基硅）丙酯合成随机嵌段共聚物；然后借助自制的底喷式流化床反应器将共聚物溶液均匀喷涂于玻璃球基表面，并利用高温退火作用实现共聚物与玻璃球基之间的键合，从而形成共聚物/玻璃球基复合载体。同时，对共聚物在玻璃球基表面的包衣效果进行初步考察，包括特征官能团、表面微观结构、生物相容性和温度响应性等。结果表明，通过底喷包衣技术可将温度响应性共聚物链接于玻璃球基表面，且能形成一定厚度的膜层。这种复合载体具有良好的生物相容性，能利用其智能响应特性实现细胞的有效黏附和自发脱附。

关键词: 复合载体, 智能响应性, N?异丙基丙烯酰胺, 流化床反应器, 底喷包衣技术

Abstract: A novel preparation method of smart responsive glass sphere based composite carriers was reported in this study. Firstly, random block copolymers were synthesized by free radical polymerization of N⁃isopropylacrylamide, hydroxypropyl methacrylate and 3⁃trimethoxysilypropyl methacrylate. Then, the copolymer solution was uniformly sprayed on the surfaces of glass spheres by means of a self⁃made bottom spray fluidized bed reactor, and the bonding between copolymers and glass spheres was fabricated by thermal annealing, so as to form the copolymer/glass sphere composite carriers. The coating effects of the smart copolymers on the surfaces of glass spheres were investigated, including characteristic functional groups, surface microstructure, biocompatibility and thermosensibility. The results show that the temperature⁃responsive copolymers can be linked to the surfaces of glass spheres by bottom⁃spray coating technology, and the copolymer layers with certain thickness can be formed on the sphere surfaces. The composite carriers have good biocompatibility, and can realize effective cell adhesion and spontaneous desorption by using its intelligent response characteristics.

Key words: Composite carrier, Smart responsiveness, N?isopropylacrylamide, Fluidized bed reactor, Bottom?spray coating technology

安琪，李海斌，张琪，杨磊，范晓光，王战勇. 温度响应性玻璃球基复合载体的制备及表征[J]. 辽宁石油化工大学学报, 2021, 41(1): 23-29.

An Qi， Li Haibin， Zhang Qi， Yang Lei， Fan Xiaoguang， Wang Zhanyong. Preparation and Characterization of Thermoresponsive Glass Sphere Based Composite Carriers[J]. Journal of Liaoning Petrochemical University, 2021, 41(1): 23-29.

温度响应性玻璃球基复合载体的制备及表征

Preparation and Characterization of Thermoresponsive Glass Sphere Based Composite Carriers

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