For air⁃water⁃air⁃water⁃water⁃anion exchange resin system, the effects of solid loading, particle size, separator and different guide tube forms on mass transfer coefficients were studied in an airlift cyclone reactor (HALR) with a volume of 130 L (inner diameter 290 mm and height 2 000 mm) and an apparent gas velocity of 0~0.84 cm/s. The results showed that the volumetric mass transfer coefficients of the three phases system were larger than the two phases. As the particle size increased, the volumetric mass transfer coefficients decreased. The volumetric mass transfer coefficients with the solid separator was a little bigger than the none of separator.The volumetric mass transfer coefficient of the finned draft tube was the largest when the superficial gas velocity was small.