Abstract: The copolymer of PAANa －co－PVP was prepared by copolymerization of acrylate and N －vinyl pyrrolidone，intiated with the NH_３· H_２ O／H_２O_２redoxy intiator．The structure of the copolymer was characterized via FTIR method．It is educed that the reactivity ratio of AANa（r_１） and NVP（r_２） is 3.296 and 0.808 respectively，by analyzing the reactivity ratio results calculated by mathematical methods of FR，KT and YBR， via the aid of the test results of element analysis．The extrinsic cytotoxicity of the copolymer was evaluated through the 3-4,5－dimethylthiazol －2－yl －2,5－diphenyltetrazolium bromide （MTT） reduction assay．It is found that the copolymer is biocompatible．

Key words: Copolymerization , Reactivity ratio , Cytotoxicity

摘要： 通过 NH ₃ · H ₂ O/ H ₂ O ₂ 氧化还原引发体系引发丙烯酸钠( AANa)与乙烯基吡咯烷酮(NVP)共聚，制备了PAANa - co - PVP共聚物。通过FTIR对共聚产物进行了结构表征。在元素分析表征的基础上，采用FR法， KT法和YBR法对采用NH ₃ ·H ₂ O/ H ₂ O ₂ 引发时，AANa与 NVP共聚的竞聚率( r ₁，r ₂)进行了计算，其值分别为3 .296，0 .808。采用MTT法对所制备产物的体外细胞毒性进行了研究，结果表明所制备的产物具有良好的生物相容性。

关键词: 共聚 , 竞聚率 , 细胞毒性