An elemental-direct-reaction has been carried out to synthesis CuS with sulfur powder and copper powder. CuS with diameter of 1～2 μm is successfully synthesized in deep eutectic solvent of tetrapropylammonium bromide and ethylene glycol (molar ratio=1∶3). It was found that the optimized reaction condition was 25 ℃ by changing reaction parameters such as temperature and time. XRD analysis showed the product was highly purity. SEM indicated the surface of each CuS spheres were covered with many nanoflakes interconnected with each other. UV-Vis analysis showed that the product had strong absorption in both ultraviolet and visible region, the band gap energy of the product was approximately 1.59 eV. The asprepared CuS was tested by the degradation of methylene blue, Rhodamine B and methyl orange under the irradiation of UV Lamp. The degradation rate were up to 94.99%, 89.90%, 69.42% in 60 min and it showed its excellent photocatalytic activity. Moreover, the test also showed that the addition of H ₂O ₂ played an important role in the experiment.