As the declining of oil, coal and other fossil fuel, and the rising of environmental pollution and greenhouse's effect, natural gas, as a kind of high efficient and clean energy, has been given a great attention and favour by the countries all over the world. Natural gas liquefaction and storage technology is key to its use and development. The latest theory research shows that the construction of long distance LNG pipeline is feasible in technology and reasonable in the economy. However the researches of the liquefaction station of long distance LNG pipeline are few. The liquefaction process of the liquefaction station along the long distance LNG pipelines was discussed. Through the analysis on the reverse Carnot cycle, combined with cooling characteristics of refrigerant such as propane, ethylene, methane, liquefaction process of liquefaction station along long-distance LNG pipeline was proposed and related equipments were selected.