1-氯-2,4,5-三甲基苯的合成方法

石油化工高等学校学报 ›› 2008, Vol. 21 ›› Issue (2): 53-54.

1-氯-2,4,5-三甲基苯的合成方法

刘琳, 邢锦娟, 钱建华* , 张庆春

(渤海大学应用化学重点实验室,辽宁锦州121000)

收稿日期:2007-09-22 出版日期:2008-06-20 发布日期:2017-06-28
作者简介:刘琳(1965-),女,河北唐山市,教授,博士
基金资助:
辽宁省教育厅科学计划项目(2005033)。

The Synthesis of 1-Chloro-2,4,5-Trimethyl-Benzene

LIU Lin， XING Jin-juan， QIAN Jian-huan*， ZHANG Qin-chun

(Applied Chemistry Key Laborary，BoHai University, Jinzhou Liaoning 121000,P.R.China)

Received:2007-09-22 Published:2008-06-20 Online:2017-06-28

摘要/Abstract

摘要： 以偏三甲苯为原料,HCl-H₂O₂-CH₃COOH 为催化活化体系,一步法合成1-氯-2,4,5-三甲基苯,通过正交实验,考察了影响反应的各种因素,确定了反应的最佳条件:温度为60 ℃,H₂O₂ 与偏三甲苯(TMB)的摩尔比为4.5,HCl与TMB的摩尔比为4∶1,进料完全后反应时间为2h,在此条件下反应的原料转化率为98.4%,产品收率为82.8%,纯度为99%。

关键词: 催化活化, 1-氯-2,4,5-三甲基苯, 一步法

Abstract:

1-Chloro-2,4,5-trimethyl-benzene was synthesized by one-step method, unsym- trimethylbenzene as the raw material, while HCl-H₂O₂-CH₃COOH as the catalytic activity system. By the orthorhombic experiment, the influenced factors are considered and the optimum conditions are confirmed. The experiment was carried under 60℃ for 2 h, while the mole ratio of H₂O₂ and unsym- trimethylbenzene is 4.5, HCl and unsym- trimethylbenzene is 4.0. The average yield was 82.8%, and the conversion rate was 98.4% while the fineness 99% under those conditions.

Key words:

Catalytic activity, 1-Chloro-2,4,5-trimethyl-benzene, One-step method

刘琳, 邢锦娟, 钱建华,张庆春. 1-氯-2,4,5-三甲基苯的合成方法[J]. 石油化工高等学校学报, 2008, 21(2): 53-54.

LIU Lin， XING Jin-juan， QIAN Jian-huan， ZHANG Qin-chun.

The Synthesis of 1-Chloro-2,4,5-Trimethyl-Benzene

[J]. Journal of Petrochemical Universities, 2008, 21(2): 53-54.