Because of the natural life of the pipeline and the impact of artificial factors, pipeline leakage accidents occur frequently. It is very important to detect pipeline leaks and determine the leak location to minimize damage and maintain the safe operation of the pipeline. Be aimed at the products pipeline leak, the CFD simulation software was used to simulate changes in the pipeline pressure. Once the pressure changed at the pipe end and beginning, the pipeline leak happened somewhere. Then under the pressure gradient changes of the pipeline end and beginning, the pressure gradient method was used to ultimately determine the leak location of the pipeline. 