Abstract:

Heterocyclic N?oxides are important structural units in organic synthesis and pharmaceutical molecules. Under mild conditions, the combination of visible?light catalysis and transition metal catalysis can simply and efficiently realize the direct ortho?C—H bond acylation reaction of heterocyclic N?oxides and benzoyl formic acid. The reaction system has good universality and excellent selectivity, and can obtain a series of N?oxides substituted by ortho?acyl groups at a moderate to good yield.

Key words: Visible?light, N?oxides, α?oxocarboxylic acids, Acylation reaction

摘要：

杂环氮氧化物是有机合成和药物分子中重要的结构单元，在温和条件下利用可见光催化与过渡金属催化相结合，可简单高效地实现杂环氮氧化物与苯甲酰甲酸的直接邻位C—H酰基化反应。该反应体系具有良好的普适性与优异的选择性，能够以中等到良好的产率得到一系列邻位酰基取代的氮氧化物。

关键词: 可见光, 氮氧化物, α?羰基羧酸, 酰化反应