Abstract: A variety of novel chiral phosphoric acid catalysts were synthesized from R⁃binaphthol via hydroxyl protection, halogenation, coupling, deprotection, phosphorylation and hydrolysis. The chiral phosphoric acid catalysts synthesized were mainly chiral phosphoric acid catalysts with nitro substituents, because the addition of nitro substituents could increase the acidity of phosphoric acid and provide a catalyst for some reactions requiring a stronger acidic catalytic system. By our method, about 10 g of nitro⁃substituted chiral phosphoric acid catalyst could be synthesized in one time in a high yield, which provided great convenience for asymmetric catalytic reaction.

Key words: Chiral phosphoric acid, Coupling, Asymmetry, Catalysts

摘要： 以R⁃联萘酚为原料，经过羟基保护、卤代、偶联、脱保护、磷酰化、水解等步骤高效合成多种新型手性磷酸催化剂。合成的手性磷酸催化剂以硝基取代基手性磷酸催化剂为主，因为硝基取代基的加入可以增加磷酸的酸性，为一些需要较强酸性催化体系的反应提供催化剂。该方法以较高的产率一次性合成10 g左右硝基取代的手性磷酸催化剂，为不对称催化反应提供了极大的便利。

关键词: 手性磷酸, 偶联反应, 不对称, 催化剂