The experiments of residence time distribution in SK static mixer were done by using the pulse tracer method. The effect of different factors on residence time distribution was evaluated based on mixed orthogonal experiments. The results of range analysis showed that the factors impacting the mean residence time were velocity, diameter, cross section, and arrange mode of elements in turn; but for variance the factors were diameter, cross section, velocity, and arrange mode of elements in turn. From the comparison of residence time distribution curves, the flow in the static mixer tended to be plug flow along the axial direction at the same velocity and diameter. The quantization analysis, the effect of factors on the mean residence time, was done by using the power function considering the numbers of mixer element, diameter and velocity, and so on. The validity of this function was testified by the experiment results of Di=40 mm and the mean error was 12%. The variance value was larger at lower flow rate due to the “wall flow”. The results of the variance analysis agreed with the previous analysis of residence time distribution curves.